Chronic Rejection

Chronic rejection in renal transplantation

Curbing culprits of chronic rejection

Diamonds to the rescue Keeping track of spin transport inside a spintronic device is challenging. Du et al. came up with a method involving diamond nitrogen-vacancy (NV) centers, which can act like tiny, very sensitive magnetometers. The authors placed diamond nanobeams containing the NV centers in close proximity to the sample. This allowed them to measure the spin chemical potential of spin w...

Chronic rejection: failure of immune regulation.

Current strategies for immunosuppression following organ transplantation focus on the prevention of acute rejection. As new generations of immunosuppressants have been developed, acute rejection rates have diminished markedly. The new challenge, then, is to prevent the devastating complications of chronic rejection, which have remained largely unchanged over the decades. The process of chronic ...

Mechanisms of chronic cardiac allograft rejection.

Chronic rejection in the form of cardiac allograft vasculopathy is one of the major factors that affects long-term graft and patient survival after heart transplantation. Whereas multiple factors contribute to the development of cardiac allograft vasculopathy, immunologic mechanisms play the predominant role in the chronic rejection process, because both alloimmune and autoimmune responses are ...

Autoimmune retinopathy after chronic renal allograft rejection.

tient’s baseline anticoagulant therapy contributed to the unusually slow progression of vision loss. A few reports propose beneficial effects of anticoagulation and antiplatelet therapy in GCA-related vision loss. Buono et al reported improvement in acuity and posterior ciliary artery blood flow with the addition of heparin sodium therapy in a patient with progressive visual loss despite cortic...